An hour after exercise the permeability level of the cell membrane increases sharply. Exercise does make the body fit, but exercise without the right physical exercise guidelines actually harm our health. When done with high intensity in the long term, physical exercise that resulted in tissue damage.
After exercise and cooling, blood lactic acid (ALD) levels increased by 59%. Increased ALD will cause permeability (permeability rate) of the increased cell membrane. The effects of such processes are those materials that normally do not pass through cell membranes to free in and out of the cell. Traffic arrangement of substances from outside and inside the cell becomes uncontrolled resulting in network damage. The higher the intensity of physical exercise will be the more reactive oxidant compounds (SOR) that cannot be neutralized in the body.
This tissue damage is seen from increased levels of the enzyme Creatine Phosphokinase (CPK) and Lactic Dehydrogenase (LDH). These two enzymes are a sign of cell membrane breakdown. These enzymes will begin to increase in the fifth minute after undergoing physical exercise. The enzymes will continue to increase until the 60th minute. In aerobic exercise, these enzymes increase only by 20-36% at 60 minutes. In anaerobic exercise, these enzymes increase by 60%.
This suggests that cell membrane permeability rates are very high after physical exercise. The higher the intensity of physical exercise, the higher the SOR production the more severe the damage to the network. The enzymes that mark the destruction of these tissues are most commonly found in muscles. CPK is found in skeletal muscle, whereas LDH is found in the heart muscle and skeleton.
Actually, a high physical exercise load will stimulate skeletal muscle cells. This will also stimulate the antioxidant system in fast and slow type muscles. The more trained one, the higher the response and the capacity of the antioxidant enzyme. The main problem to be considered is how to set up an exercise program that can improve the physical condition and the ability of the anti-oxidant system without having to ignore the damage to the network it is causing.